BDBM150175 US8980901, 107::US9149477, Compound 107

SMILES CC[C@H](Nc1ncnc2[nH]cnc12)c1nc2cccc(F)c2c(=O)n1-c1ccccc1

InChI Key InChIKey=IFSDAJWBUCMOAH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 150175   

LigandPNGBDBM150175(US8980901, 107 | US9149477, Compound 107)
Affinity DataIC50: 64nMAssay Description:Inhibition of human PI3Kgamma (S144 to A1102 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
LigandPNGBDBM150175(US8980901, 107 | US9149477, Compound 107)
Affinity DataIC50: 9nMAssay Description:Using the method described in Example 2, compounds of the invention were tested for inhibitory activity and potency against PI3Kdelta, and for select...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

LigandPNGBDBM150175(US8980901, 107 | US9149477, Compound 107)
Affinity DataIC50: 9nMAssay Description:Using the method described in US9149477, Example 2, compounds of the invention were tested for inhibitory activity and potency against PI3Kδ, an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2016
Entry Details
Go to US Patent

LigandPNGBDBM150175(US8980901, 107 | US9149477, Compound 107)
Affinity DataIC50: 2nMAssay Description:Inhibition of human PI3Kdelta (R108 to Q1044 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed