BDBM15221 1-Hydroxyisoquinoline-5-sulfonic acid (2S,4S)-(2-(4-chlorobenzyloxymethyl)pyrrolidin-4-yl)amide::N-[(3S,5S)-5-{[(4-chlorophenyl)methoxy]methyl}pyrrolidin-3-yl]-1-hydroxyisoquinoline-5-sulfonamide::isoquinoline-5-sulfonamide 65

SMILES Clc1ccc(COC[C@@H]2C[C@@H](CN2)NS(=O)(=O)c2cccc3c2cc[nH]c3=O)cc1

InChI Key InChIKey=XKMQBIJUNONHHA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 15221   

TargetRAC-beta serine/threonine-protein kinase(Human)
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15221(N-[(3S,5S)-5-{[(4-chlorophenyl)methoxy]methyl}pyrr...)
Affinity DataIC50: 520nMAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2007
Entry Details Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bovine)
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15221(N-[(3S,5S)-5-{[(4-chlorophenyl)methoxy]methyl}pyrr...)
Affinity DataIC50: 1.30E+3nMAssay Description:The recombinant alpha catalytic subunit of bovine PKA was assayed with a peptide substrate and test compound in the presence of 40 uM ATP/ [gamma-33P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2007
Entry Details Article
PubMed