BDBM152467 1-(4-Fluorophenyl)-3-(4-(6-nitro-2-oxo-2H-chromen-3-yl)thiazol-2-yl)urea (e31)

SMILES [O-][N+](=O)c1ccc2oc(=O)c(cc2c1)-c1csc(NC(=O)Nc2ccc(F)cc2)n1

InChI Key InChIKey=KFBRZPHJODPHCN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 152467   

TargetAcetylcholinesterase(Electric eel)
Bezmialem Vakif University

LigandPNGBDBM152467(1-(4-Fluorophenyl)-3-(4-(6-nitro-2-oxo-2H-chromen-...)
Affinity DataIC50: 1.35E+5nMpH: 8.0Assay Description:The substrates of the reaction were acetylthiocholine iodide and butyrylthiocholine iodide. 5,5'-dithio-bis(2-nitrobenzoic) acid (DTNB) was used ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
Bezmialem Vakif University

LigandPNGBDBM152467(1-(4-Fluorophenyl)-3-(4-(6-nitro-2-oxo-2H-chromen-...)
Affinity DataIC50: 4.93E+3nMpH: 8.0Assay Description:The substrates of the reaction were acetylthiocholine iodide and butyrylthiocholine iodide. 5,5'-dithio-bis(2-nitrobenzoic) acid (DTNB) was used ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details Article
PubMed
TargetCholinesterase(Horse)
Abbottabad University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM152467(1-(4-Fluorophenyl)-3-(4-(6-nitro-2-oxo-2H-chromen-...)
Affinity DataIC50: 4.93E+3nMAssay Description:Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2020
Entry Details Article
PubMed