BDBM15304 (5R)-6-[4-({2-[(2-methoxyphenyl)methyl]-3-oxocyclohex-1-en-1-yl}amino)phenyl]-5-methyl-2,3,4,5-tetrahydropyridazin-3-one::dihydropyridazinone 14a

SMILES COc1ccccc1CC1=C(CCCC1=O)Nc1ccc(cc1)C1=NNC(=O)C[C@H]1C

InChI Key InChIKey=COEVDPWUZRPZIC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 15304   

TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B [387-1112](Human)
Merck Research Laboratories

LigandPNGBDBM15304((5R)-6-[4-({2-[(2-methoxyphenyl)methyl]-3-oxocyclo...)
Affinity DataIC50: 0.130nMpH: 7.5 T: 2°CAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2007
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A [388-1112](Human)
Merck Research Laboratories

LigandPNGBDBM15304((5R)-6-[4-({2-[(2-methoxyphenyl)methyl]-3-oxocyclo...)
Affinity DataIC50: 0.390nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2007
Entry Details Article
PubMed