BDBM158155 US10081622, Compound 4::US9029356, 4::US9255087, 4::US9616059, 4

SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2ccc(Cc3cc(F)cc(F)c3)cc12

InChI Key InChIKey=IBWUYNSLISMPFY-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 158155   

TargetALK tyrosine kinase receptor(Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM158155(US9029356, 4 | US9255087, 4 | US10081622, Compound...)
Affinity DataIC50: 207nMpH: 7.5Assay Description:ALK enzyme needs pre-activation in order to linearize reaction kinetics.Kinase Buffer (KB) for ALKKinase buffer was composed of 50 mM HEPES pH 7.5 co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2015
Entry Details
Go to US Patent

TargetInsulin-like growth factor 1 receptor(Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM158155(US9029356, 4 | US9255087, 4 | US10081622, Compound...)
Affinity DataIC50: 2.35E+3nMAssay Description:The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.A spe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2015
Entry Details
Go to US Patent

TargetAurora kinase B(Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM158155(US9029356, 4 | US9255087, 4 | US10081622, Compound...)
Affinity DataIC50: 484nMAssay Description:The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.A spe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2015
Entry Details
Go to US Patent

TargetInsulin-like growth factor 1 receptor(Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM158155(US9029356, 4 | US9255087, 4 | US10081622, Compound...)
Affinity DataIC50: 1.44E+3nMAssay Description:Inhibition of IGF1R (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM158155(US9029356, 4 | US9255087, 4 | US10081622, Compound...)
Affinity DataIC50: 1.81E+3nMAssay Description:Inhibition of IR (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM158155(US9029356, 4 | US9255087, 4 | US10081622, Compound...)
Affinity DataIC50: 73nMAssay Description:Inhibition of recombinant ALK (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Shanghai Institute of Pharmaceutical Industry Co., Ltd

Curated by ChEMBL
LigandPNGBDBM158155(US9029356, 4 | US9255087, 4 | US10081622, Compound...)
Affinity DataIC50: 0.850nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed