BDBM158157 US10081622, Compound 18::US9029356, 18::US9255087, 18::US9616059, 18

SMILES CN1CCN(CC1)c1ccc(C(=O)Nc2n[nH]c3ccc(Cc4cc(F)cc(F)c4)cc23)c(NC2CCCCC2)c1

InChI Key InChIKey=VHSQRCDULUNORA-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 158157   

TargetALK tyrosine kinase receptor(Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM158157(US9029356, 18 | US9255087, 18 | US10081622, Compou...)
Affinity DataIC50: 1.77E+3nMpH: 7.5Assay Description:ALK enzyme needs pre-activation in order to linearize reaction kinetics.Kinase Buffer (KB) for ALKKinase buffer was composed of 50 mM HEPES pH 7.5 co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2015
Entry Details
Go to US Patent

TargetInsulin-like growth factor 1 receptor(Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM158157(US9029356, 18 | US9255087, 18 | US10081622, Compou...)
Affinity DataIC50: 6.07E+3nMAssay Description:The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.A spe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2015
Entry Details
Go to US Patent

TargetAurora kinase B(Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM158157(US9029356, 18 | US9255087, 18 | US10081622, Compou...)
Affinity DataIC50: 3.23E+3nMAssay Description:The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.A spe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2015
Entry Details
Go to US Patent

TargetInsulin receptor(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM158157(US9029356, 18 | US9255087, 18 | US10081622, Compou...)
Affinity DataIC50: 3.82E+3nMAssay Description:Inhibition of IR (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM158157(US9029356, 18 | US9255087, 18 | US10081622, Compou...)
Affinity DataIC50: 560nMAssay Description:Inhibition of recombinant ALK (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed