BDBM159149 US10093663, Example 5-3::US9682968, Example-5-2::US9682968, Example-5-3

SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCC(CO)CC1c1ccccc1

InChI Key InChIKey=GPVRSVAIVVQZMJ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 159149   

TargetComplement factor B(Human)
Novartis

US Patent
LigandPNGBDBM159149(US9682968, Example-5-3 | US9682968, Example-5-2 | ...)
Affinity DataIC50: 2.60nMAssay Description:CVF-Bb complex prepared from purified cobra venom factor (1 uM), recombinant human complement factor B (expressed in drosophila cells and purified us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2018
Entry Details
US Patent

TargetComplement factor B(Human)
Novartis

US Patent
LigandPNGBDBM159149(US9682968, Example-5-3 | US9682968, Example-5-2 | ...)
Affinity DataIC50: 7.90nMAssay Description:CVF-Bb complex prepared from purified cobra venom factor (1 uM), recombinant human complement factor B (expressed in drosophila cells and purified us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2018
Entry Details
US Patent

TargetComplement factor B(Human)
Novartis

US Patent
LigandPNGBDBM159149(US9682968, Example-5-3 | US9682968, Example-5-2 | ...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of human serine protease factor B by TR-FRET based competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetComplement factor B(Human)
Novartis

US Patent
LigandPNGBDBM159149(US9682968, Example-5-3 | US9682968, Example-5-2 | ...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of human serine protease factor B by TR-FRET based competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetComplement factor B(Human)
Novartis

US Patent
LigandPNGBDBM159149(US9682968, Example-5-3 | US9682968, Example-5-2 | ...)
Affinity DataIC50: 2.60E+3nMpH: 7.4 T: 2°CAssay Description:CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/22/2019
Entry Details
US Patent

TargetComplement factor B(Human)
Novartis

US Patent
LigandPNGBDBM159149(US9682968, Example-5-3 | US9682968, Example-5-2 | ...)
Affinity DataIC50: 7.90E+3nMpH: 7.4 T: 2°CAssay Description:CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/22/2019
Entry Details
US Patent