BDBM1606 2-cyclopropyl-7-[(2-hydroxy-4-methylphenyl)methyl]-2,4,9,15-tetraazatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3,5,7,12,14-hexaen-10-one::Nevirapin 4-substituted deriv. 4ac::ll-Cyclopropyl-5,1 l-dihydro-4-[ (2-hydroxy-4-methylphenyl)methy1]-6H-dipyrido[3,2-b:2 ,3 -e] [1,4]diazepin-6-one

SMILES Cc1ccc(Cc2ccnc3N(C4CC4)c4ncccc4C(=O)Nc23)c(O)c1

InChI Key InChIKey=ZBRYMJQGTZVHEN-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 1606   

TargetGag-Pol polyprotein [600-1027,R876K]/[600-1155](Human immunodeficiency virus type 1)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM1606(2-cyclopropyl-7-[(2-hydroxy-4-methylphenyl)methyl]...)
Affinity DataIC50: 200nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2004
Entry Details Article
PubMed