BDBM161225 US10087143, Compound 10::US10738009, Compound 10::US10787472, Compound 9a::US11673864, Compound 10::US9051270, 10::US9163042, 9a::US9758483, Compound 10

SMILES Cc1cc(F)ccc1Oc1cc(ccc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F

InChI Key InChIKey=YXHMFJXQQXHKRO-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 161225   

TargetSodium channel protein type 10 subunit alpha(Rat)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM161225(US9163042, 9a | US9051270, 10 | US10087143, Compou...)
Affinity DataIC50: 14nMAssay Description:Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2016
Entry Details
US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM161225(US9163042, 9a | US9051270, 10 | US10087143, Compou...)
Affinity DataIC50: 14nMAssay Description:Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM161225(US9163042, 9a | US9051270, 10 | US10087143, Compou...)
Affinity DataIC50: 14nMAssay Description:Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2021
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM161225(US9163042, 9a | US9051270, 10 | US10087143, Compou...)
Affinity DataIC50: 14nMAssay Description:1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM161225(US9163042, 9a | US9051270, 10 | US10087143, Compou...)
Affinity DataIC50: 14nMAssay Description:Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
US Patent

TargetSodium channel protein type 10 subunit alpha(Rat)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM161225(US9163042, 9a | US9051270, 10 | US10087143, Compou...)
Affinity DataIC50: 14nMAssay Description:Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2016
Entry Details
US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM161225(US9163042, 9a | US9051270, 10 | US10087143, Compou...)
Affinity DataIC50: 14nMAssay Description:1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details
US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM161225(US9163042, 9a | US9051270, 10 | US10087143, Compou...)
Affinity DataIC50: 16nMAssay Description:A capillary glass pipette (BF150-86-10, Sutter Instruments) was pulled into a recording electrode with a micropipette puller (P97, Sutter Instruments...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2025
Entry Details
US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM161225(US9163042, 9a | US9051270, 10 | US10087143, Compou...)
Affinity DataIC50: 35.1nMAssay Description:Clamped the cell at −80 mV and then depolarized to 10 mV with a square wave lasting 10 ms to get the Nav1.8 current (see FIG. 1 attached). This proce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2025
Entry Details
US Patent