BDBM162989 US9056865, A-116

SMILES Cc1cnc(c(C)c1)-c1cc(ncc1Cl)N1CCN(CC1)C(=O)CCS(C)(=O)=O

InChI Key InChIKey=BBVNTTZIOTWDSV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 162989   

TargetSmoothened homolog(Human)
Pfizer

US Patent
LigandPNGBDBM162989(US9056865, A-116)
Affinity DataIC50: 6.80nMT: 2°CAssay Description:For the binding competition assay, 100 μL of Assay Buffer was added to all the wells of a 96 well GF/B filter plate (Millipore MultiScreen-HTS-F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2016
Entry Details
Go to US Patent

TargetSmoothened homolog(Human)
Pfizer

US Patent
LigandPNGBDBM162989(US9056865, A-116)
Affinity DataIC50: 5.80nMAssay Description:Binding affinity to human SMO (181 to 787 residues) expressed in human HEK293 cells assessed as radioactivity incubated for 2 hrs in presence of H3-l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed