BDBM163421 US9687479, 288 N-[(5-chlorothiophen-2-yl)methyl]-1-[(furan-3-yl)carbonyl]-3-(pyridin-2-yl)-1H-pyrazol-5-amine::US9687479, 293 N-[(5-chlorothiophen-2-yl)methyl]-3-(pyridin-2-yl)-1-[(thiophen-3-yl)carbonyl]-1H-pyrazol-5-amine

SMILES Clc1ccc(CNc2cc(nn2C(=O)c2ccoc2)-c2ccccn2)s1

InChI Key InChIKey=BYVJWTIMUGEKIN-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 163421   

TargetProthrombin(Human)
Verseon

Curated by ChEMBL
LigandPNGBDBM163421(US9687479, 288 N-[(5-chlorothiophen-2-yl)methyl]-1...)
Affinity DataIC50: 9nMAssay Description:Inhibition of human thrombin using S-2238 as chromogenic substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetPlasma kallikrein(Human)
Verseon

US Patent
LigandPNGBDBM163421(US9687479, 288 N-[(5-chlorothiophen-2-yl)methyl]-1...)
Affinity DataIC50: 550nMpH: 7.4 T: 2°CAssay Description:Human KLKB1 protein was obtained from Enzyme Research Labs. The chromogenic substrate S-2302 was obtained from DiaPharma. KLKB1 was assayed in buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2018
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Verseon

US Patent
LigandPNGBDBM163421(US9687479, 288 N-[(5-chlorothiophen-2-yl)methyl]-1...)
Affinity DataIC50: 5.50E+4nMpH: 7.4 T: 2°CAssay Description:Human KLKB1 protein was obtained from Enzyme Research Labs. The chromogenic substrate S-2302 was obtained from DiaPharma. KLKB1 was assayed in buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2018
Entry Details
US Patent

TargetKallikrein-1(Human)
Verseon

US Patent
LigandPNGBDBM163421(US9687479, 288 N-[(5-chlorothiophen-2-yl)methyl]-1...)
Affinity DataIC50: 1.00E+5nMpH: 7.5 T: 2°CAssay Description:Recombinant human tissue kallikrein (KLK1) was obtained from R&D Systems. Pro-Phe-Arg-AMC (I-1295) substrate was obtained from Bachem. KLK1 enzyme is...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2018
Entry Details
US Patent