BDBM164057 US9062078, 187::US9475819, 187::US9637496, 187::US9695183, 187

SMILES Cc1ccc(c(n1)C(=O)N1C2CCC1C(C2)Nc1ccc(cn1)C(F)(F)F)-n1nccn1

InChI Key InChIKey=ZIVMVPNFNDQFRD-UHFFFAOYSA-N

Data  14 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 164057   

TargetOrexin/Hypocretin receptor type 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM164057(US9475819, 187 | US9062078, 187 | US9695183, 187 |...)
Affinity DataKi:  48nM ΔG°:  -9.27kcal/moleT: 2°CAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2017
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM164057(US9475819, 187 | US9062078, 187 | US9695183, 187 |...)
Affinity DataKi:  48nMAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM164057(US9475819, 187 | US9062078, 187 | US9695183, 187 |...)
Affinity DataKi:  48nM ΔG°:  -9.27kcal/moleT: 2°CAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2018
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM164057(US9475819, 187 | US9062078, 187 | US9695183, 187 |...)
Affinity DataKi:  48nM ΔG°:  -9.27kcal/moleT: 2°CAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM001525) or Chinese ovary cells (CHO) s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2016
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM164057(US9475819, 187 | US9062078, 187 | US9695183, 187 |...)
Affinity DataKi:  75nMAssay Description:Binding affinity to human OXIRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM164057(US9475819, 187 | US9062078, 187 | US9695183, 187 |...)
Affinity DataKi:  81nMAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM164057(US9475819, 187 | US9062078, 187 | US9695183, 187 |...)
Affinity DataKi:  81nM ΔG°:  -10.2kcal/moleT: 2°CAssay Description:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2016
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM164057(US9475819, 187 | US9062078, 187 | US9695183, 187 |...)
Affinity DataKi:  81nM ΔG°:  -8.99kcal/moleT: 2°CAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2018
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM164057(US9475819, 187 | US9062078, 187 | US9695183, 187 |...)
Affinity DataKi:  81nM ΔG°:  -8.99kcal/moleT: 2°CAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2017
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM164057(US9475819, 187 | US9062078, 187 | US9695183, 187 |...)
Affinity DataKi:  620nMAssay Description:Binding affinity to human OX2RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM164057(US9475819, 187 | US9062078, 187 | US9695183, 187 |...)
Affinity DataKi:  620nM ΔG°:  -8.89kcal/moleT: 2°CAssay Description:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2016
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM164057(US9475819, 187 | US9062078, 187 | US9695183, 187 |...)
Affinity DataKi:  620nM ΔG°:  -8.89kcal/moleT: 2°CAssay Description:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat # SH30022), 10%...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2018
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM164057(US9475819, 187 | US9062078, 187 | US9695183, 187 |...)
Affinity DataKi:  620nMAssay Description:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM164057(US9475819, 187 | US9062078, 187 | US9695183, 187 |...)
Affinity DataKi:  620nM ΔG°:  -8.89kcal/moleT: 2°CAssay Description:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2017
Entry Details
US Patent