BDBM16676 Mixture of trans methyl(cyclopropylmethyl)diastereomers.::N-[(2S,3S)-3-amino-1-(3,5-difluorophenyl)heptan-2-yl]-2-({[(1S,2S)-2-methylcyclopropyl]methyl}amino)-6-(N-methylmethanesulfonamido)pyridine-4-carboxamide::isonicotinamide, 15

SMILES CCCC[C@H](N)[C@H](Cc1cc(F)cc(F)c1)NC(=O)c1cc(NC[C@H]2C[C@@H]2C)nc(c1)N(C)S(C)(=O)=O

InChI Key InChIKey=RKDSHPWKIYQWRO-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 16676   

TargetBeta-secretase 1(Human)
Merck Research Laboratories

LigandPNGBDBM16676(Mixture of trans methyl(cyclopropylmethyl)diastere...)
Affinity DataIC50: 9nMT: 2°CAssay Description:HEK293T cells were stably transfected with APP_NFEV. One day after plating, the cells were treated for 20-24 h with a medium containing a compound or...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed