BDBM167545 US9073922, 29::US9796708, Example 29

SMILES COc1cc(F)ccc1-c1ccnc2[nH]c(cc12)C1CCN(C)CC1

InChI Key InChIKey=MYGCBFRVFDUTBD-UHFFFAOYSA-N

Data  4 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 167545   

TargetCyclin-dependent kinase 9(Human)
Abbvie

US Patent
LigandPNGBDBM167545(US9073922, 29 | US9796708, Example 29)
Affinity DataIC50: 23nMAssay Description:CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/29/2016
Entry Details
Go to US Patent

TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Abbvie

US Patent
LigandPNGBDBM167545(US9073922, 29 | US9796708, Example 29)
Affinity DataIC50: 23nMAssay Description:CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 9(Human)
Abbvie

US Patent
LigandPNGBDBM167545(US9073922, 29 | US9796708, Example 29)
Affinity DataIC50: 10nMAssay Description:Inhibition of CDK9 (unknown origin) using FITC-X-GSRTPMY-NH2 as substrate preincubated for 10 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 9(Human)
Abbvie

US Patent
LigandPNGBDBM167545(US9073922, 29 | US9796708, Example 29)
Affinity DataIC50: 71nMAssay Description:Inhibition of CDK9 in human MCF7 cells assessed as reduction in RNA polymerase II phosphorylation at ser2 residue incubated for 6 hrs by fluorescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCaspase-3/Caspase-7(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM167545(US9073922, 29 | US9796708, Example 29)
Affinity DataEC50:  75nMAssay Description:Activation of caspase 3/7 in human MV4-11 cells incubated for 6 hrs by Caspase-Glo 3/7 reagent based microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed