BDBM168281 US9669031, 109 8-chloro-6-(pyrimidin-4-ylamino)spiro[2H-imidazo[1,5-a]pyridine-3,1′-cyclohexane]-1,5-dione hydrochloride (Cpd. No. 109)

SMILES Clc1cc(Nc2ccncn2)c(=O)n2c1C(=O)NC21CCCCC1

InChI Key InChIKey=OEVBYHNIUPOXDX-UHFFFAOYSA-N

Data  4 KI  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 168281   

TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Effector Therapeutics

US Patent
LigandPNGBDBM168281(US9669031, 109 8-chloro-6-(pyrimidin-4-ylamino)spi...)
Affinity DataIC50: 10nMT: 2°CAssay Description:Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2018
Entry Details
Go to US Patent

TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM168281(US9669031, 109 8-chloro-6-(pyrimidin-4-ylamino)spi...)
Affinity DataIC50: 5.80nMAssay Description:Competitive inhibition of recombinant GST-tagged MNK1 (unknown origin) using eIF4E derived peptide as substrate at Km concentration in presence of AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM168281(US9669031, 109 8-chloro-6-(pyrimidin-4-ylamino)spi...)
Affinity DataIC50: 6nMAssay Description:Competitive inhibition of recombinant GST-tagged MNK1 (unknown origin) using eIF4E derived peptide as substrate in presence of ATP at concentration o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Effector Therapeutics

US Patent
LigandPNGBDBM168281(US9669031, 109 8-chloro-6-(pyrimidin-4-ylamino)spi...)
Affinity DataIC50: 1.5nMAssay Description:Competitive inhibition of recombinant His-tagged MNK2 (unknown origin) using eIF4E derived peptide as substrate at concentration of Km/10 in presence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Effector Therapeutics

US Patent
LigandPNGBDBM168281(US9669031, 109 8-chloro-6-(pyrimidin-4-ylamino)spi...)
Affinity DataIC50: 1.5nMAssay Description:Competitive inhibition of recombinant His-tagged MNK2 (unknown origin) using eIF4E derived peptide as substrate at Km concentration in presence of AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM168281(US9669031, 109 8-chloro-6-(pyrimidin-4-ylamino)spi...)
Affinity DataIC50: 4nMAssay Description:Competitive inhibition of recombinant GST-tagged MNK1 (unknown origin) using eIF4E derived peptide as substrate in presence of ATP at concentration o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM168281(US9669031, 109 8-chloro-6-(pyrimidin-4-ylamino)spi...)
Affinity DataIC50: 4nMAssay Description:Competitive inhibition of recombinant GST-tagged MNK1 (unknown origin) using eIF4E derived peptide as substrate in presence of ATP at Km concentratio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Effector Therapeutics

US Patent
LigandPNGBDBM168281(US9669031, 109 8-chloro-6-(pyrimidin-4-ylamino)spi...)
Affinity DataIC50: 5nMAssay Description:Competitive inhibition of recombinant His-tagged MNK2 (unknown origin) using eIF4E derived peptide as substrate in presence of ATP at concentration o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Effector Therapeutics

US Patent
LigandPNGBDBM168281(US9669031, 109 8-chloro-6-(pyrimidin-4-ylamino)spi...)
Affinity DataIC50: 5nMAssay Description:Competitive inhibition of recombinant His-tagged MNK2 (unknown origin) using eIF4E derived peptide as substrate in presence of ATP at Km concentratio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Effector Therapeutics

US Patent
LigandPNGBDBM168281(US9669031, 109 8-chloro-6-(pyrimidin-4-ylamino)spi...)
Affinity DataIC50: 4nMAssay Description:Competitive inhibition of recombinant His-tagged MNK2 (unknown origin) using eIF4E derived peptide as substrate in presence of ATP at concentration o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Effector Therapeutics

US Patent
LigandPNGBDBM168281(US9669031, 109 8-chloro-6-(pyrimidin-4-ylamino)spi...)
Affinity DataIC50: 2nMAssay Description:Competitive inhibition of recombinant His-tagged MNK2 (unknown origin) using eIF4E derived peptide as substrate at concentration of 10XKm in presence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM168281(US9669031, 109 8-chloro-6-(pyrimidin-4-ylamino)spi...)
Affinity DataIC50: 4.70nMAssay Description:Competitive inhibition of recombinant GST-tagged MNK1 (unknown origin) using eIF4E derived peptide as substrate at concentration of Km/10 in presence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM168281(US9669031, 109 8-chloro-6-(pyrimidin-4-ylamino)spi...)
Affinity DataIC50: 3.5nMAssay Description:Competitive inhibition of recombinant GST-tagged MNK1 (unknown origin) using eIF4E derived peptide as substrate at concentration of 10XKm in presence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM168281(US9669031, 109 8-chloro-6-(pyrimidin-4-ylamino)spi...)
Affinity DataIC50: 10nMT: 2°CAssay Description:Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2018
Entry Details
Go to US Patent

TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM168281(US9669031, 109 8-chloro-6-(pyrimidin-4-ylamino)spi...)
Affinity DataKi:  2nMAssay Description:Inhibition of recombinant GST-tagged MNK1 (unknown origin) using eIF4E-derived peptide as substrate in presence of ATP at km concentration by ADP-Glo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM168281(US9669031, 109 8-chloro-6-(pyrimidin-4-ylamino)spi...)
Affinity DataKi:  2nMAssay Description:Binding affinity to Mnk1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Effector Therapeutics

US Patent
LigandPNGBDBM168281(US9669031, 109 8-chloro-6-(pyrimidin-4-ylamino)spi...)
Affinity DataKi:  3nMAssay Description:Inhibition of recombinant His-tagged MNK2 (unknown origin) using eIF4E-derived peptide as substrate in presence of ATP at Km concentration by ADP-Glo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Effector Therapeutics

US Patent
LigandPNGBDBM168281(US9669031, 109 8-chloro-6-(pyrimidin-4-ylamino)spi...)
Affinity DataKi:  30nMAssay Description:Binding affinity to Mnk2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed