BDBM168436 US9675591, SKA-19

SMILES c1cc2c(cc1SC(F)(F)F)sc(n2)N

InChI Key InChIKey=PBRVVEXJMLEKMJ-UHFFFAOYSA-N

Data  7 IC50  9 EC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 168436   

TargetSmall conductance calcium-activated potassium channel protein 1(Human)
University of California

US Patent
LigandPNGBDBM168436(US9675591, SKA-19)
Affinity DataEC50: >1.00E+5nMpH: 7.35 T: 2°CAssay Description:All experiments were conducted at room temperature (22-24° C.) with an EPC-10 amplifier and Pulse software (HEKA, Lambrecht/Pfalz, Germany) in the wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2018
Entry Details
Go to US Patent

TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
University of California

US Patent
LigandPNGBDBM168436(US9675591, SKA-19)
Affinity DataEC50:  1.40E+4nMpH: 7.35 T: 2°CAssay Description:All experiments were conducted at room temperature (22-24° C.) with an EPC-10 amplifier and Pulse software (HEKA, Lambrecht/Pfalz, Germany) in the wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2018
Entry Details
Go to US Patent

TargetSmall conductance calcium-activated potassium channel protein 3(Human)
University of California

US Patent
LigandPNGBDBM168436(US9675591, SKA-19)
Affinity DataEC50:  1.50E+4nMpH: 7.35 T: 2°CAssay Description:All experiments were conducted at room temperature (22-24° C.) with an EPC-10 amplifier and Pulse software (HEKA, Lambrecht/Pfalz, Germany) in the wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM168436(US9675591, SKA-19)
Affinity DataEC50:  6.90E+3nMpH: 7.35 T: 2°CAssay Description:All experiments were conducted at room temperature (22-24° C.) with an EPC-10 amplifier and Pulse software (HEKA, Lambrecht/Pfalz, Germany) in the wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 2 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM168436(US9675591, SKA-19)
Affinity DataEC50:  7.90E+3nMpH: 7.35 T: 2°CAssay Description:All experiments were conducted at room temperature (22-24° C.) with an EPC-10 amplifier and Pulse software (HEKA, Lambrecht/Pfalz, Germany) in the wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 3 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM168436(US9675591, SKA-19)
Affinity DataEC50:  2.20E+3nMpH: 7.35 T: 2°CAssay Description:All experiments were conducted at room temperature (22-24° C.) with an EPC-10 amplifier and Pulse software (HEKA, Lambrecht/Pfalz, Germany) in the wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 4 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM168436(US9675591, SKA-19)
Affinity DataEC50:  4.50E+3nMpH: 7.35 T: 2°CAssay Description:All experiments were conducted at room temperature (22-24° C.) with an EPC-10 amplifier and Pulse software (HEKA, Lambrecht/Pfalz, Germany) in the wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM168436(US9675591, SKA-19)
Affinity DataEC50:  5.80E+3nMpH: 7.35 T: 2°CAssay Description:All experiments were conducted at room temperature (22-24° C.) with an EPC-10 amplifier and Pulse software (HEKA, Lambrecht/Pfalz, Germany) in the wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2018
Entry Details
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TargetPotassium voltage-gated channel subfamily B member 1(Human)
University of California

US Patent
LigandPNGBDBM168436(US9675591, SKA-19)
Affinity DataEC50:  2.23E+4nMpH: 7.35 T: 2°CAssay Description:All experiments were conducted at room temperature (22-24° C.) with an EPC-10 amplifier and Pulse software (HEKA, Lambrecht/Pfalz, Germany) in the wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2018
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM168436(US9675591, SKA-19)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of Tracer Red from human ERG by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM168436(US9675591, SKA-19)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human CYP2C19 expressed in baculovirus infected insect cells using beetle D-luciferin as substrate preincubated for 30 mins followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM168436(US9675591, SKA-19)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human CYP2D6 expressed in baculovirus infected insect cells using beetle D-luciferin as substrate preincubated for 30 mins followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM168436(US9675591, SKA-19)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human CYP3A4 expressed in baculovirus infected insect cells using beetle D-luciferin as substrate preincubated for 30 mins followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetPteridine reductase 1(Leishmania major)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM168436(US9675591, SKA-19)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of Leishmania major pteridine reductase 1 using di-hydrobiopterine as substrate in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM168436(US9675591, SKA-19)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human CYP1A2 expressed in baculovirus infected insect cells using beetle D-luciferin as substrate preincubated for 30 mins followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM168436(US9675591, SKA-19)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human CYP2C9 expressed in baculovirus infected insect cells using beetle D-luciferin as substrate preincubated for 30 mins followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed