BDBM17017 (3Z)-5-methyl-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihydro-1H-indol-2-one::Indolinone based inhibitor, 1b

SMILES Cc1ccc2NC(=O)\C(=C/c3ccc[nH]3)c2c1

InChI Key InChIKey=SGKVGSSCLHVXJK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 17017   

Target3-phosphoinositide-dependent protein kinase 1(Human)
Berlex Biosciences

LigandPNGBDBM17017((3Z)-5-methyl-3-(1H-pyrrol-2-ylmethylidene)-2,3-di...)
Affinity DataIC50: 2.70E+3nMpH: 7.2 T: 2°CAssay Description:The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2007
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Milano-Bicocca

Curated by ChEMBL
LigandPNGBDBM17017((3Z)-5-methyl-3-(1H-pyrrol-2-ylmethylidene)-2,3-di...)
Affinity DataIC50: 6.60E+4nMAssay Description:Inhibition of human recombinant His-tagged RET expressed in Sf9 insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed