BDBM17028 (3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-5-hydroxy-2,3-dihydro-1H-indol-2-one::CHEMBL426078::Indolinone based inhibitor, 2f

SMILES Cc1cc(C)c(\C=C2/C(=O)Nc3ccc(O)cc23)[nH]1

InChI Key InChIKey=GUXYHZUGDWFOBA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 17028   

Target3-phosphoinositide-dependent protein kinase 1(Human)
Berlex Biosciences

LigandPNGBDBM17028(CHEMBL426078 | (3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-y...)
Affinity DataIC50: 1.10E+3nMpH: 7.2 T: 2°CAssay Description:The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2007
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Leo Pharma

Curated by ChEMBL
LigandPNGBDBM17028(CHEMBL426078 | (3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-y...)
Affinity DataIC50: 100nMAssay Description:In vitro inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed