BDBM17029 (3Z)-5-methoxy-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihydro-1H-indol-2-one::Indolinone based inhibitor, 3a

SMILES COc1ccc2NC(=O)\C(=C/c3ccc[nH]3)c2c1

InChI Key InChIKey=NUKBQTLXNISBTR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 17029   

Target3-phosphoinositide-dependent protein kinase 1(Human)
Berlex Biosciences

LigandPNGBDBM17029((3Z)-5-methoxy-3-(1H-pyrrol-2-ylmethylidene)-2,3-d...)
Affinity DataIC50: 580nMpH: 7.2 T: 2°CAssay Description:The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2007
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase tousled-like 2(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM17029((3Z)-5-methoxy-3-(1H-pyrrol-2-ylmethylidene)-2,3-d...)
Affinity DataIC50: 1.50E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed