BDBM175377 1,3-Dimethyl-8-[3-{2-(dimethylaminoethylamino)-2-oxoethoxy}-phenyl]xanthine (14a, RB-379)

SMILES CN(C)CCNC(=O)COc1cccc(c1)-c1nc2n(C)c(=O)n(C)c(=O)c2[nH]1

InChI Key InChIKey=YKXVIXWCJKBOMG-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 175377   

TargetAdenosine receptor A2a(Human)
Panjab University

LigandPNGBDBM175377(1,3-Dimethyl-8-[3-{2-(dimethylaminoethylamino)-2-o...)
Affinity DataKi:  163nMAssay Description:Dissociation constants at A1, A2A and A3 receptors (Ki-values) were determined in radioligand competition experiments as reported earlier [19,20]. Al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2016
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Panjab University

LigandPNGBDBM175377(1,3-Dimethyl-8-[3-{2-(dimethylaminoethylamino)-2-o...)
Affinity DataKi:  683nMAssay Description:Dissociation constants at A1, A2A and A3 receptors (Ki-values) were determined in radioligand competition experiments as reported earlier [19,20]. Al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2016
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
Panjab University

LigandPNGBDBM175377(1,3-Dimethyl-8-[3-{2-(dimethylaminoethylamino)-2-o...)
Affinity DataKi:  2.83E+3nMAssay Description:Dissociation constants at A1, A2A and A3 receptors (Ki-values) were determined in radioligand competition experiments as reported earlier [19,20]. Al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2016
Entry Details Article
PubMed
TargetAdenosine receptor A3 [I248L](Human)
Panjab University

LigandPNGBDBM175377(1,3-Dimethyl-8-[3-{2-(dimethylaminoethylamino)-2-o...)
Affinity DataKi:  8.97E+3nMAssay Description:Dissociation constants at A1, A2A and A3 receptors (Ki-values) were determined in radioligand competition experiments as reported earlier [19,20]. Al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2016
Entry Details Article
PubMed