BDBM17696 2-aminobenzoxazole, 21::4-({2-[(4-chlorophenyl)amino]-1,3-benzoxazol-5-yl}oxy)-N-methylpyridine-2-carboxamide

SMILES CNC(=O)c1cc(Oc2ccc3oc(Nc4ccc(Cl)cc4)nc3c2)ccn1

InChI Key InChIKey=MSLRCTIJTGCYGK-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 17696   

LigandPNGBDBM17696(4-({2-[(4-chlorophenyl)amino]-1,3-benzoxazol-5-yl}...)
Affinity DataKi:  12nM ΔG°:  -10.7kcal/molepH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2007
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM17696(4-({2-[(4-chlorophenyl)amino]-1,3-benzoxazol-5-yl}...)
Affinity DataIC50: 19nMAssay Description:Inhibition of c-Raf assessed as phosphorylation of MEK1/2 by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed