BDBM17784 2-aminoquinazoline, 2::3-[(2-amino-6-phenoxy-3,4-dihydroquinazolin-3-yl)methyl]-N-cyclohexyl-N-methylbenzamide

SMILES CN(C1CCCCC1)C(=O)c1cccc(CN2Cc3cc(Oc4ccccc4)ccc3N=C2N)c1

InChI Key InChIKey=FXTPEHCYBUSFBC-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 17784   

TargetBeta-secretase 1(Human)
Johnson & Johnson Pharmaceutical

LigandPNGBDBM17784(3-[(2-amino-6-phenoxy-3,4-dihydroquinazolin-3-yl)m...)
Affinity DataKi:  158nM ΔG°:  -9.18kcal/molepH: 5.0 T: 2°CAssay Description:BACE-1 activity was measured at pH 5 using the FS1 FRET substrate. Compounds were preincubated with recombinant BACE-1 for 20 min before adding subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2007
Entry Details Article
PubMed