BDBM17880 Ketoamide inhibitor, 10::tert-butyl N-{1-[(1R,5S)-2-[(1-carbamoyl-3,3-dimethyl-1-oxobutan-2-yl)carbamoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexan-3-yl]-3,3-dimethyl-1-oxobutan-2-yl}carbamate

SMILES CC(C)(C)OC(=O)NC(C(=O)N1C[C@H]2[C@@H](C1C(=O)NC(C(=O)C(N)=O)C(C)(C)C)C2(C)C)C(C)(C)C

InChI Key InChIKey=PXVZKSMODJNUCS-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 17880   

TargetGenome polyprotein(HCV)
Schering-Plough Research Institute

LigandPNGBDBM17880(tert-butyl N-{1-[(1R,5S)-2-[(1-carbamoyl-3,3-dimet...)
Affinity DataKi: >6.90E+4nM ΔG°: >-5.77kcal/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2007
Entry Details Article
PubMed