BDBM17942 (2R,4S,5S)-5-amino-N-butyl-4-hydroxy-2,7,7-trimethyl-9-oxo-9-(1,2,3,4-tetrahydroquinolin-1-yl)nonanamide::Renin nonpeptide inhibitor, 2

SMILES CCCCNC(=O)[C@H](C)C[C@H](O)[C@@H](N)CC(C)(C)CC(=O)N1CCCc2ccccc12

InChI Key InChIKey=BVJOWZFWZASPEA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 17942   

TargetRenin(Human)
Novartis Pharmaceuticals

LigandPNGBDBM17942((2R,4S,5S)-5-amino-N-butyl-4-hydroxy-2,7,7-trimeth...)
Affinity DataIC50: 52nMpH: 7.2 T: 2°CAssay Description:In vitro potencies of compounds against purified human recombinant renin were determined by its cleavage of substrate angiotensinogen. The angiotensi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2007
Entry Details Article
PubMed
TargetPepsin A(Pig)
Novartis Pharmaceuticals

LigandPNGBDBM17942((2R,4S,5S)-5-amino-N-butyl-4-hydroxy-2,7,7-trimeth...)
Affinity DataIC50: 1.00E+5nMpH: 2.0 T: 2°CAssay Description:In vitro potencies of compounds against purified porcine pepsin were determined by its cleavage of substrate hemoglobin. After incubation, proteins w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2007
Entry Details Article
PubMed