BDBM179798 3-(1-(2,6-dichloro-3-fluorophenyl)ethyl)-2-methyl-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine (6)

SMILES CC(c1c(C)[nH]c2ncc(cc12)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl

InChI Key InChIKey=FEQNECCIEFZWKT-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 179798   

TargetIsoform 2 of Hepatocyte growth factor receptor (2)(Human)
Tianjin University of Science and Technology

LigandPNGBDBM179798(3-(1-(2,6-dichloro-3-fluorophenyl)ethyl)-2-methyl-...)
Affinity DataIC50: 286nMpH: 7.0 T: 2°CAssay Description:The c-Met kinase activity of five target compounds and three positive compounds were evaluated using standard Z-LYTE Assays (fluorescence resonance e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2016
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Tianjin University of Science and Technology

LigandPNGBDBM179798(3-(1-(2,6-dichloro-3-fluorophenyl)ethyl)-2-methyl-...)
Affinity DataIC50: 504nMpH: 7.5 T: 2°CAssay Description:The ALK kinase activity of five target compounds and three positive compounds were evaluated using standard homogeneous time-resolved fluorescence (H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2016
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor [C1156Y](Human)
Tianjin University of Science and Technology

LigandPNGBDBM179798(3-(1-(2,6-dichloro-3-fluorophenyl)ethyl)-2-methyl-...)
Affinity DataIC50: 1.52E+3nMpH: 7.5 T: 2°CAssay Description:The ALK kinase activity of five target compounds and three positive compounds were evaluated using standard homogeneous time-resolved fluorescence (H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2016
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor [L1196M](Human)
Tianjin University of Science and Technology

LigandPNGBDBM179798(3-(1-(2,6-dichloro-3-fluorophenyl)ethyl)-2-methyl-...)
Affinity DataIC50: 1.66E+3nMpH: 7.5 T: 2°CAssay Description:The ALK kinase activity of five target compounds and three positive compounds were evaluated using standard homogeneous time-resolved fluorescence (H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2016
Entry Details Article
PubMed