BDBM18034 Ketopiperazine-based inhibitor, 14

SMILES COc1ccccc1COCCCOc1ccc(cc1)N1[C@@H](COc2ccc3OCC(=O)N(CC(O)=O)c3c2)CNCC1=O

InChI Key InChIKey=XTVVJSSQHZOGSY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 18034   

TargetRenin(Human)
Pfizer

LigandPNGBDBM18034(Ketopiperazine-based inhibitor, 14)
Affinity DataIC50: 364nMpH: 7.4 T: 2°CAssay Description:The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2007
Entry Details Article
PubMed