BDBM181143 US9138393, Immepip dihydrobromide::US9144538, Immepip dihydrobromide

SMILES C(C1CCCNC1)c1c[nH]cn1

InChI Key InChIKey=KPAJJCMZSUJZLQ-UHFFFAOYSA-N

Data  3 KI  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 181143   

TargetHistamine H3 receptor(Human)
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM181143(US9138393, Immepip dihydrobromide | US9144538, Imm...)
Affinity DataEC50:  49nMAssay Description:Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM181143(US9138393, Immepip dihydrobromide | US9144538, Imm...)
Affinity DataKi:  68nMAssay Description:Displacement of [3H]-NR-methylhistamine from human histamine H3 receptor expressed in SK-N-MC cells by liquid scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM181143(US9138393, Immepip dihydrobromide | US9144538, Imm...)
Affinity DataKi:  68nMAssay Description:Inhibitory activity measured by [3H]- N alpha- methyl-histamine binding to membranes of SK-N-MC cells expressing the human Histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM181143(US9138393, Immepip dihydrobromide | US9144538, Imm...)
Affinity DataKi:  616nMAssay Description:Inhibitory activity measured by [3H]- N alpha- methyl-histamine binding to membranes of SK-N-MC cells expressing the human Histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM181143(US9138393, Immepip dihydrobromide | US9144538, Imm...)
Affinity DataEC50:  3.98E+3nMAssay Description:Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
The Procter & Gamble

US Patent
LigandPNGBDBM181143(US9138393, Immepip dihydrobromide | US9144538, Imm...)
Affinity DataIC50: 1.00E+4nMAssay Description:A commercially available P450-GLO Assay kit (Promega Corporation, Madison Wis.) is used to screen various compounds for CYP3A4A inhibition activity. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2016
Entry Details
US Patent

TargetCytochrome P450 3A4(Human)
The Procter & Gamble

US Patent
LigandPNGBDBM181143(US9138393, Immepip dihydrobromide | US9144538, Imm...)
Affinity DataIC50: 1.00E+4nMAssay Description:Cytochrome P450 is a large and diverse group of enzymes that catalyze the oxidation of organic substances. Some members of the CYP family contribute ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2016
Entry Details
US Patent