BDBM18197 1-(2,2,2-trifluoroethyl)-9-(trifluoromethyl)-1H,2H,3H,6H,7H-quinolino[7,6-b][1,4]oxazin-7-one::7H-[1,4]Oxazino[3,2-g]quinolin-7-one based compound, 10f

SMILES FC(F)(F)CN1CCOc2cc3[nH]c(=O)cc(c3cc12)C(F)(F)F

InChI Key InChIKey=DKTPAKMQCCCINA-UHFFFAOYSA-N

Data  3 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 18197   

TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18197(1-(2,2,2-trifluoroethyl)-9-(trifluoromethyl)-1H,2H...)
Affinity DataKi:  4nM ΔG°:  -11.9kcal/mole EC50:  3.5nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2007
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18197(1-(2,2,2-trifluoroethyl)-9-(trifluoromethyl)-1H,2H...)
Affinity DataKi:  5.30E+3nM ΔG°:  -6.69kcal/molepH: 7.4 T: 2°CAssay Description:The procedure for the cross reactivity receptor binding assays was using baculovirus-expressed receptors. After correcting for nonspecific binding, I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2007
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18197(1-(2,2,2-trifluoroethyl)-9-(trifluoromethyl)-1H,2H...)
Affinity DataKi:  9.20E+3nM ΔG°:  -6.38kcal/molepH: 7.4 T: 2°CAssay Description:The procedure for the cross reactivity receptor binding assays was using baculovirus-expressed receptors. After correcting for nonspecific binding, I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2007
Entry Details Article
PubMed