BDBM183984 US9150566, 21

SMILES Cc1ccc(c(C(=O)N2CCOC[C@H]2Cc2cccc(c2)-n2cccn2)c1F)-n1nccn1

InChI Key InChIKey=KTJOHPLNNYAVJM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 183984   

TargetOrexin/Hypocretin receptor type 1(Human)
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM183984(US9150566, 21)
Affinity DataIC50: 2nMT: 2°CAssay Description:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2016
Entry Details
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TargetOrexin receptor type 2(Human)
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM183984(US9150566, 21)
Affinity DataIC50: 1.65E+3nMT: 2°CAssay Description:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2016
Entry Details
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TargetCytochrome P450 3A4(Human)
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM183984(US9150566, 21)
Affinity DataIC50: 2.00E+4nMpH: 7.4 T: 2°CAssay Description:The CYP3A4 inhibition assay was performed using human liver microsomes and testosterone 6'-hydroxylation as a P450 isoform-specific marker. In a tota...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2016
Entry Details
Go to US Patent