BDBM18509 7-{3-[(2,4-diaminopyrimidin-5-yl)methyl]-4-methoxyphenyl}hept-6-ynoic acid::CHEMBL33922::Diaminopyrimidine, 21

SMILES COc1ccc(cc1Cc1cnc(N)nc1N)C#CCCCCC(O)=O

InChI Key InChIKey=CIUYZEMTWPMSNU-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 18509   

TargetDihydrofolate reductase(Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG...)
University of Connecticut At Storrs

LigandPNGBDBM18509(CHEMBL33922 | 7-{3-[(2,4-diaminopyrimidin-5-yl)met...)
Affinity DataIC50: 6.93E+4nMpH: 7.0 T: 2°CAssay Description:Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18509(CHEMBL33922 | 7-{3-[(2,4-diaminopyrimidin-5-yl)met...)
Affinity DataIC50: 870nMAssay Description:Inhibition of Dihydrohydrofolate reductase(DHFR) of Pneumocystis cariniiMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Mycobacterium avium)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18509(CHEMBL33922 | 7-{3-[(2,4-diaminopyrimidin-5-yl)met...)
Affinity DataIC50: 41nMAssay Description:Inhibition of Dihydrohydrofolate reductase(DHFR) of Mycobacterium aviumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18509(CHEMBL33922 | 7-{3-[(2,4-diaminopyrimidin-5-yl)met...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition Dihydrohydrofolate reductase(DHFR) of rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18509(CHEMBL33922 | 7-{3-[(2,4-diaminopyrimidin-5-yl)met...)
Affinity DataIC50: 72nMAssay Description:Inhibitory activity against Dihydrohydrofolate reductase(DHFR) of Toxoplasma gondiiMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed