BDBM185556 US20250051337, Compound 11::US9156845, 215

SMILES NC(=O)c1cccc(c1)-c1c[nH]c2ncnc(N3CCOCC3)c12

InChI Key InChIKey=NCXSLSJEOUOJBB-UHFFFAOYSA-N

Data  4 KI  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 185556   

LigandPNGBDBM185556(US9156845, 215 | US20250051337, Compound 11)
Affinity DataIC50: 30.6nMpH: 7.5Assay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2016
Entry Details
Go to US Patent

LigandPNGBDBM185556(US9156845, 215 | US20250051337, Compound 11)
Affinity DataIC50: 79.3nMpH: 7.5Assay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2016
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase 4(Human)
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM185556(US9156845, 215 | US20250051337, Compound 11)
Affinity DataIC50: 50nMAssay Description:Inhibition of recombinant N-terminal His6-tagged human STK4 (43 to 431 residues) expressed in Escherichia coli using myelin basic protein as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase 3(Human)
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM185556(US9156845, 215 | US20250051337, Compound 11)
Affinity DataIC50: 233nMAssay Description:Inhibition of recombinant N-terminal His6-tagged human STK3 (18 to 311 residues) expressed in Escherichia coli using myelin basic protein as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase 3(Human)
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM185556(US9156845, 215 | US20250051337, Compound 11)
Affinity DataIC50: 303nMAssay Description:Displacement of K5 tracer from full length C-terminal NanoLuc fused human STK3 expressed in HEK293T cells incubated for 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase 4(Human)
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM185556(US9156845, 215 | US20250051337, Compound 11)
Affinity DataIC50: 259nMAssay Description:Displacement of K5 tracer from full length C-terminal NanoLuc fused human STK4 expressed in HEK293T cells incubated for 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
LigandPNGBDBM185556(US9156845, 215 | US20250051337, Compound 11)
Affinity DataIC50: 2.36E+3nMAssay Description:Displacement of K5 tracer from full length C-terminal NanoLuc fused human LRRK2 expressed in HEK293T cells incubated for 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase 4(Human)
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM185556(US9156845, 215 | US20250051337, Compound 11)
Affinity DataIC50: 1.00E+3nMAssay Description:The STK3 kinase assay was performed in 5 μL reaction buffer containing 50 ng recombinant human STK3 protein (full length, SignalChem #S24-10G; Richmo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2025
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase 3(Human)
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM185556(US9156845, 215 | US20250051337, Compound 11)
Affinity DataIC50: 1.00E+3nMAssay Description:The STK3 kinase assay was performed in 5 μL reaction buffer containing 50 ng recombinant human STK3 protein (full length, SignalChem #S24-10G; Richmo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2025
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase 4(Human)
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM185556(US9156845, 215 | US20250051337, Compound 11)
Affinity DataKi:  91nMAssay Description:Recombinant kinase domains of STK3 and STK4 at 2.0 μM in 10 mM HEPES pH 7.5 and 500 mM NaCl were mixed with 10 UM of the test inhibitors. Temperature...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2025
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase 4(Human)
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM185556(US9156845, 215 | US20250051337, Compound 11)
Affinity DataKi:  96nMAssay Description:Binding affinity to recombinant N-terminal His6-tagged human STK4 (43 to 431 residues) expressed in Escherichia coli assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase 3(Human)
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM185556(US9156845, 215 | US20250051337, Compound 11)
Affinity DataKi:  145nMAssay Description:Recombinant kinase domains of STK3 and STK4 at 2.0 μM in 10 mM HEPES pH 7.5 and 500 mM NaCl were mixed with 10 UM of the test inhibitors. Temperature...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2025
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase 3(Human)
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM185556(US9156845, 215 | US20250051337, Compound 11)
Affinity DataKi:  150nMAssay Description:Binding affinity to recombinant N-terminal His6-tagged human STK3 (18 to 311 residues) expressed in Escherichia coli assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed