BDBM185700 US10875847, Compound Oclacitinib::US9161939, 1a::US9271981, 1a

SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2[nH]ccc12

InChI Key InChIKey=HJWLJNBZVZDLAQ-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 185700   

TargetTyrosine-protein kinase JAK1(Human)
Zoetis Services

US Patent
LigandPNGBDBM185700(US9271981, 1a | US9161939, 1a | US10875847, Compou...)
Affinity DataIC50: 9.53nMpH: 7.4Assay Description:Methods: A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK-2 and JAK-3) or the IRS-1 peptide (JAK-1 and Tyk...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2016
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Zoetis Services

US Patent
LigandPNGBDBM185700(US9271981, 1a | US9161939, 1a | US10875847, Compou...)
Affinity DataIC50: 17.5nMpH: 7.4Assay Description:Methods: A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK-2 and JAK-3) or the IRS-1 peptide (JAK-1 and Tyk...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2016
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Zoetis Services

US Patent
LigandPNGBDBM185700(US9271981, 1a | US9161939, 1a | US10875847, Compou...)
Affinity DataIC50: 95.1nMpH: 7.4Assay Description:Methods: A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK-2 and JAK-3) or the IRS-1 peptide (JAK-1 and Tyk...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2016
Entry Details
Go to US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Zoetis Services

US Patent
LigandPNGBDBM185700(US9271981, 1a | US9161939, 1a | US10875847, Compou...)
Affinity DataIC50: 75.1nMpH: 7.4Assay Description:Methods: A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK-2 and JAK-3) or the IRS-1 peptide (JAK-1 and Tyk...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2016
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [852-1142](Human)
Zoetis Services

US Patent
LigandPNGBDBM185700(US9271981, 1a | US9161939, 1a | US10875847, Compou...)
Affinity DataIC50: 9.53nMpH: 7.4Assay Description:Methods: A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK-2 and JAK-3) or the IRS-1 peptide (JAK-1 and Tyk...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2 [809-1153](Human)
Zoetis Services

US Patent
LigandPNGBDBM185700(US9271981, 1a | US9161939, 1a | US10875847, Compou...)
Affinity DataIC50: 17.5nMpH: 7.4Assay Description:Methods: A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK-2 and JAK-3) or the IRS-1 peptide (JAK-1 and Tyk...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3 [781-1124](Human)
Zoetis Services

US Patent
LigandPNGBDBM185700(US9271981, 1a | US9161939, 1a | US10875847, Compou...)
Affinity DataIC50: 95.1nMpH: 7.4Assay Description:Methods: A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK-2 and JAK-3) or the IRS-1 peptide (JAK-1 and Tyk...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details
Go to US Patent

TargetNon-receptor tyrosine-protein kinase TYK2 [870-1187](Human)
Zoetis Services

US Patent
LigandPNGBDBM185700(US9271981, 1a | US9161939, 1a | US10875847, Compou...)
Affinity DataIC50: 75.1nMpH: 7.4Assay Description:Methods: A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK-2 and JAK-3) or the IRS-1 peptide (JAK-1 and Tyk...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Zoetis Services

US Patent
LigandPNGBDBM185700(US9271981, 1a | US9161939, 1a | US10875847, Compou...)
Affinity DataIC50: 18nMAssay Description:Inhibition of human recombinant JAK2 (808 to 1132 residues) by Z-Lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Zoetis Services

US Patent
LigandPNGBDBM185700(US9271981, 1a | US9161939, 1a | US10875847, Compou...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant JAK1 (852 to 1142 residues) by Z-Lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Zoetis Services

US Patent
LigandPNGBDBM185700(US9271981, 1a | US9161939, 1a | US10875847, Compou...)
Affinity DataIC50: 3.40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
Go to US Patent