BDBM186829 US9670203, Compound 1.21

SMILES Fc1ccccc1NC(=O)N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12

InChI Key InChIKey=KGUYRZDURTZEOU-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 186829   

LigandPNGBDBM186829(US9670203, Compound 1.21)
Affinity DataIC50: 1.10E+3nMT: 2°CAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
Go to US Patent

LigandPNGBDBM186829(US9670203, Compound 1.21)
Affinity DataIC50: 66nMT: 2°CAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM186829(US9670203, Compound 1.21)
Affinity DataIC50: 1.10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM186829(US9670203, Compound 1.21)
Affinity DataIC50: 0.0660nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM186829(US9670203, Compound 1.21)
Affinity DataIC50: 0.870nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed