BDBM188145 US9670194, Ex. 4 (S)-2-(1-((6-amino-5-(3-methyl-1,2,4-oxadiazol-5-yl)pyrimidin-4-yl)amino)-propyl)-5-chloro-3-cyclopropylquinazolin-4(3H)-one

SMILES CC[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1nc2cccc(Cl)c2c(=O)n1C1CC1

InChI Key InChIKey=XHQKEWGONWROCR-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 188145   

LigandPNGBDBM188145(US9670194, Ex. 4 (S)-2-(1-((6-amino-5-(3-methyl-1,...)
Affinity DataIC50: 1.48E+3nMT: 2°CAssay Description:PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2018
Entry Details
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LigandPNGBDBM188145(US9670194, Ex. 4 (S)-2-(1-((6-amino-5-(3-methyl-1,...)
Affinity DataIC50: 113nMT: 2°CAssay Description:PI3K (p110β/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol-4,5-bisphosphate and MgATP (concentration as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2018
Entry Details
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LigandPNGBDBM188145(US9670194, Ex. 4 (S)-2-(1-((6-amino-5-(3-methyl-1,...)
Affinity DataIC50: 8nMT: 2°CAssay Description:PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2018
Entry Details
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LigandPNGBDBM188145(US9670194, Ex. 4 (S)-2-(1-((6-amino-5-(3-methyl-1,...)
Affinity DataIC50: 258nMT: 2°CAssay Description:PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2018
Entry Details
Go to US Patent