BDBM188518 ISOX-INACT

SMILES COc1ccc(CCc2nc3c(C)c(-c4c(C)noc4C)c(C)cc3n2CCN2CCOCC2)cc1

InChI Key InChIKey=FTOHXUPHICJSCR-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 188518   

TargetCREB-binding protein(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM188518(ISOX-INACT)
Affinity DataIC50: 1.06E+4nMAssay Description:Inhibition of CREBBP (unknown origin) by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2019
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM188518(ISOX-INACT)
Affinity DataIC50: 1.06E+4nMAssay Description:The assay used His-tagged CBP protein, biotinylated histone H4, and detection reagents europium-labeled streptavidin and anti-6His antibody labeled w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM188518(ISOX-INACT)
Affinity DataIC50: 1.20E+5nMAssay Description:Inhibition of BRD4 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2019
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM188518(ISOX-INACT)
Affinity DataIC50: 1.20E+5nMAssay Description:The assay used a Cy5 dye-labeled BRD inhibitor PFI-411FP. The synthesis of the probe and the procedure for the assay was reported recently (Hett et a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed