BDBM189351 4-(4-Methylpiperazin-1-yl)-6-(2-methylpropyl)-1,3,5-triazin-2-amine (10)

SMILES CC(C)Cc1nc(N)nc(n1)N1CCN(C)CC1

InChI Key InChIKey=XAZKFIZTFFYRIR-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 189351   

TargetHistamine H4 receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM189351(4-(4-Methylpiperazin-1-yl)-6-(2-methylpropyl)-1,3,...)
Affinity DataKi:  529nMAssay Description:Displacement of [3H]-histamine from recombinant human H4 receptor expressed in Sf9 cell membranes co-expressing Galphai2/Gbeta1gamma2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM189351(4-(4-Methylpiperazin-1-yl)-6-(2-methylpropyl)-1,3,...)
Affinity DataKi:  8.26E+3nM ΔG°:  -6.44kcal/molepH: 7.4 T: 2°CAssay Description:Prior to the experiments, cell membranes were sedimented by a 10 min centrifugation at 4 °C and 16 0009x g and resuspended in binding buffer (12....More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/3/2016
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM189351(4-(4-Methylpiperazin-1-yl)-6-(2-methylpropyl)-1,3,...)
Affinity DataKi:  8.26E+3nMAssay Description:Displacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed