BDBM189352 4-(4-Methylpiperazin-1-yl)-6-(naphthalen-1-ylmethyl)-1,3,5-triazin-2-amine (12)

SMILES CN1CCN(CC1)c1nc(N)nc(Cc2cccc3ccccc23)n1

InChI Key InChIKey=ZJCMJVPWMYOZEM-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 189352   

Target5-hydroxytryptamine receptor 6(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM189352(4-(4-Methylpiperazin-1-yl)-6-(naphthalen-1-ylmethy...)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]-LSD from human 5-HT6R expressed in human HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2019
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Jagiellonian University Medical College

LigandPNGBDBM189352(4-(4-Methylpiperazin-1-yl)-6-(naphthalen-1-ylmethy...)
Affinity DataKi:  5.60E+3nM ΔG°:  -6.66kcal/molepH: 7.4 T: 2°CAssay Description:Prior to the experiments, cell membranes were sedimented by a 10 min centrifugation at 4 °C and 16 0009x g and resuspended in binding buffer (12....More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/3/2016
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Jagiellonian University Medical College

LigandPNGBDBM189352(4-(4-Methylpiperazin-1-yl)-6-(naphthalen-1-ylmethy...)
Affinity DataKi:  5.60E+3nMAssay Description:Displacement of [3H]histamine from human H4R expressed in Sf9 cell membranes co-expressed with G protein Gai2 and Gb1gamma2 incubated for 60 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed