BDBM189863 US9670196, 1.7 (1S,4R or 1R,4S)-4- hydroxy-2,2-dimethyl-4- (5-(3-methyl-5-((4- methylfuro[3,2- d]pyrimidin-2- yl)amino)phenyl)thiazol- 2- yl)cyclohexanecarboxylic acid

SMILES Cc1cc(Nc2nc(C)c3occc3n2)cc(c1)-c1cnc(s1)[C@@]1(O)CC[C@H](C(O)=O)C(C)(C)C1

InChI Key InChIKey=NLJOPMIQVPXQNY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 189863   

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM189863(US9670196, 1.7 (1S,4R or 1R,4S)-4- hydroxy-2,2-dim...)
Affinity DataIC50: 13.2nMpH: 7.5 T: 2°CAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2018
Entry Details
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