BDBM189866 US9670196, 2.2 (1S,4R or 1R,4S)-4- hydroxy-2,2-dimethyl-4-(5- {3-methyl-5-[(6-methyl- 1,7-naphthyridin-8- yl)amino]phenyl}-1,3- thiazol-2- yl)cyclohexanecarboxylic acid

SMILES Cc1cc(Nc2nc(C)cc3cccnc23)cc(c1)-c1cnc(s1)[C@@]1(O)CCC(C(O)=O)C(C)(C)C1

InChI Key InChIKey=LJZFQNIKHWMBMO-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 189866   

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM189866(US9670196, 2.2 (1S,4R or 1R,4S)-4- hydroxy-2,2-dim...)
Affinity DataIC50: 2.33E+3nMpH: 7.5 T: 2°CAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2018
Entry Details
US Patent