BDBM189869 US9670196, 2.5 (R or S)-4-(1-hydroxy-1-{5- [3-methyl-5- ([1,2,4]triazolo[1,5- a]pyridin-2- ylamino)phenyl]-1,3- thiazol-2-yl}ethyl)benzoic acid::US9670196, 2.6 (R or S)-4-(1-hydroxy-1-{5- [3-methyl-5- ([1,2,4]triazolo[1,5- a]pyridin-2- ylamino)phenyl]-1,3- thiazol-2-yl}ethyl)benzoic acid

SMILES Cc1cc(Nc2nc3ccccn3n2)cc(c1)-c1cnc(s1)C(C)(O)c1ccc(cc1)C(O)=O

InChI Key InChIKey=XTHIGHRWMCKDKL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 189869   

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM189869(US9670196, 2.6 (R or S)-4-(1-hydroxy-1-{5- [3-meth...)
Affinity DataIC50: 6.47nMpH: 7.5 T: 2°CAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM189869(US9670196, 2.6 (R or S)-4-(1-hydroxy-1-{5- [3-meth...)
Affinity DataIC50: 1.17nMpH: 7.5 T: 2°CAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2018
Entry Details
Go to US Patent