BDBM19456 4-(3-{4-[2-(dimethylamino)ethoxy]phenyl}-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl)phenol::Pyrazolo[1,5-a]pyrimidine, 12b

SMILES CN(C)CCOc1ccc(cc1)-c1c(nn2c(cc(nc12)C(F)(F)F)C(F)(F)F)-c1ccc(O)cc1

InChI Key InChIKey=XFPSQRFNGMCQFG-UHFFFAOYSA-N

Data  2 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 19456   

TargetEstrogen receptor(Human)
University of Illinois At Urbana-Champaign

LigandPNGBDBM19456(4-(3-{4-[2-(dimethylamino)ethoxy]phenyl}-5,7-bis(t...)
Affinity DataKi:  47nM ΔG°:  -9.15kcal/mole EC50:  1.00E+3nMpH: 7.5 T: 2°CAssay Description:Relative binding affinities were determined by a competitive radiometric binding assay using [3H]estradiol as tracer, and purified full-length human ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2007
Entry Details Article
PubMed
TargetEstrogen receptor beta(Human)
University of Illinois At Urbana-Champaign

LigandPNGBDBM19456(4-(3-{4-[2-(dimethylamino)ethoxy]phenyl}-5,7-bis(t...)
Affinity DataKi:  178nM ΔG°:  -8.43kcal/mole EC50:  250nMpH: 7.5 T: 2°CAssay Description:Relative binding affinities were determined by a competitive radiometric binding assay using [3H]estradiol as tracer, and purified full-length human ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2007
Entry Details Article
PubMed