BDBM19458 4-(2-{4-[2-(dimethylamino)ethoxy]phenyl}-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl)phenol::Pyrazolo[1,5-a]pyrimidine, 12d

SMILES CN(C)CCOc1ccc(cc1)-c1nn2c(cc(nc2c1-c1ccc(O)cc1)C(F)(F)F)C(F)(F)F

InChI Key InChIKey=LJLNVVPIWMIDOU-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 19458   

TargetEstrogen receptor beta(Human)
University of Illinois At Urbana-Champaign

LigandPNGBDBM19458(4-(2-{4-[2-(dimethylamino)ethoxy]phenyl}-5,7-bis(t...)
Affinity DataKi:  156nM ΔG°:  -8.50kcal/molepH: 7.5 T: 2°CAssay Description:Relative binding affinities were determined by a competitive radiometric binding assay using [3H]estradiol as tracer, and purified full-length human ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2007
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
University of Illinois At Urbana-Champaign

LigandPNGBDBM19458(4-(2-{4-[2-(dimethylamino)ethoxy]phenyl}-5,7-bis(t...)
Affinity DataKi:  408nM ΔG°:  -7.98kcal/molepH: 7.5 T: 2°CAssay Description:Relative binding affinities were determined by a competitive radiometric binding assay using [3H]estradiol as tracer, and purified full-length human ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2007
Entry Details Article
PubMed