BDBM195799 US9206188, 50::US9834551, Example 50

SMILES Cc1n[nH]c2ncc(cc12)-c1ccc(Cl)c(NC(=O)C=C)c1

InChI Key InChIKey=IIVMYNDXTSFVTC-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 195799   

TargetTyrosine-protein kinase ITK/TSK(Human)
Arrien Pharmaceuticals

US Patent
LigandPNGBDBM195799(US9206188, 50 | US9834551, Example 50)
Affinity DataIC50: 30nMAssay Description:1H-pyrrolo[2,3-b]pyridine, 1H-pyrazolo[3,4-b]pyridine and 5H-pyrrolo[2,3-b]pyrazine series of compounds exhibited over >100 fold selective against Ja...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2016
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Arrien Pharmaceuticals

US Patent
LigandPNGBDBM195799(US9206188, 50 | US9834551, Example 50)
Affinity DataIC50: 739nMAssay Description:1H-pyrrolo[2,3-b]pyridine, 1H-pyrazolo[3,4-b]pyridine and 5H-pyrrolo[2,3-b]pyrazine series of compounds exhibited over >100 fold selective against Ja...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2016
Entry Details
Go to US Patent

TargetTyrosine-protein kinase ITK/TSK(Human)
Arrien Pharmaceuticals

US Patent
LigandPNGBDBM195799(US9206188, 50 | US9834551, Example 50)
Affinity DataIC50: 35nMAssay Description:1H-pyrrolo[2,3-b]pyridine, 1H-pyrazolo[3,4-b]pyridine and 5H-pyrrolo[2,3-b]pyrazine series of compounds exhibited over >100 fold selective against Ja...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2016
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Arrien Pharmaceuticals

US Patent
LigandPNGBDBM195799(US9206188, 50 | US9834551, Example 50)
Affinity DataIC50: 5nMAssay Description:1H-pyrrolo[2,3-b]pyridine, 1H-pyrazolo[3,4-b]pyridine and 5H-pyrrolo[2,3-b]pyrazine series of compounds exhibited over >100 fold selective against Ja...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2016
Entry Details
Go to US Patent

TargetTyrosine-protein kinase ITK/TSK(Human)
Arrien Pharmaceuticals

US Patent
LigandPNGBDBM195799(US9206188, 50 | US9834551, Example 50)
Affinity DataIC50: 100nMAssay Description:ITK and JAK3 Kinase assay procedures:Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Arrien Pharmaceuticals

US Patent
LigandPNGBDBM195799(US9206188, 50 | US9834551, Example 50)
Affinity DataIC50: 100nMAssay Description:ITK and JAK3 Kinase assay procedures:Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details
Go to US Patent