BDBM195883 US9670213, Compound 028 2-(3-aminophenylamino)-8-(4-methoxyphenyl)-7(8H)-pteridin-one

SMILES COc1ccc(cc1)-n1c2nc(Nc3cccc(N)c3)ncc2ncc1=O

InChI Key InChIKey=FZEFYHUOKWGELA-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 195883   

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM195883(US9670213, Compound 028 2-(3-aminophenylamino)-8-(...)
Affinity DataIC50: 34nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM195883(US9670213, Compound 028 2-(3-aminophenylamino)-8-(...)
Affinity DataIC50: 3.53E+3nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
East China University of Science & Technology

Curated by ChEMBL
LigandPNGBDBM195883(US9670213, Compound 028 2-(3-aminophenylamino)-8-(...)
Affinity DataIC50: 3.84E+3nMAssay Description:Inhibition of EGFR T790M/L858R double mutant (unknown origin) using Tyr 4 peptide as substrate after 1.5 hrs by FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Blk(Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM195883(US9670213, Compound 028 2-(3-aminophenylamino)-8-(...)
Affinity DataIC50: 7.95E+3nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
East China University of Science & Technology

Curated by ChEMBL
LigandPNGBDBM195883(US9670213, Compound 028 2-(3-aminophenylamino)-8-(...)
Affinity DataIC50: 8.04E+3nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) using Tyr 4 peptide as substrate after 1.5 hrs by FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM195883(US9670213, Compound 028 2-(3-aminophenylamino)-8-(...)
Affinity DataIC50: 1.06E+4nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM195883(US9670213, Compound 028 2-(3-aminophenylamino)-8-(...)
Affinity DataIC50: 1.83E+4nMAssay Description:Inhibition of wild type EGFR (unknown origin) using Tyr 4 peptide as substrate after 1.5 hrs by FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor [L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM195883(US9670213, Compound 028 2-(3-aminophenylamino)-8-(...)
Affinity DataIC50: 1.89E+4nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent