BDBM19616 (2S)-3-cyclohexyl-2-[(5-fluoro-1,3-benzoxazol-2-yl)amino]-N-{2-[(4-fluorophenyl)amino]ethyl}propanamide::Heterocyclic arylaminoethyl amide, 7b

SMILES Fc1ccc(NCCNC(=O)[C@H](CC2CCCCC2)Nc2nc3cc(F)ccc3o2)cc1

InChI Key InChIKey=AFEWGFHFGCROEB-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 19616   

TargetCathepsin S(Human)
Gnf

LigandPNGBDBM19616((2S)-3-cyclohexyl-2-[(5-fluoro-1,3-benzoxazol-2-yl...)
Affinity DataKi:  197nM ΔG°:  -9.51kcal/molepH: 5.5 T: 2°CAssay Description:The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2007
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Gnf

LigandPNGBDBM19616((2S)-3-cyclohexyl-2-[(5-fluoro-1,3-benzoxazol-2-yl...)
Affinity DataKi:  8.37E+3nMAssay Description:The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2007
Entry Details Article
PubMed
TargetCathepsin K(Human)
Gnf

LigandPNGBDBM19616((2S)-3-cyclohexyl-2-[(5-fluoro-1,3-benzoxazol-2-yl...)
Affinity DataKi: >3.00E+4nMAssay Description:The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2007
Entry Details Article
PubMed