BDBM19707 (2S)-3-cyclohexyl-2-[(2R)-oxolan-2-ylformamido]-N-[(2S)-1-{[4-(trifluoromethoxy)phenyl]amino}propan-2-yl]propanamide::arylaminoethyl amide deriv. 21

SMILES C[C@@H](CNc1ccc(OC(F)(F)F)cc1)NC(=O)[C@H](CC1CCCCC1)NC(=O)[C@H]1CCCO1

InChI Key InChIKey=JZPVDDNAUOMUOJ-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 19707   

TargetCathepsin S(Human)
Gnf

LigandPNGBDBM19707((2S)-3-cyclohexyl-2-[(2R)-oxolan-2-ylformamido]-N-...)
Affinity DataKi:  18nM ΔG°:  -11.0kcal/molepH: 5.5 T: 2°CAssay Description:The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2007
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Gnf

LigandPNGBDBM19707((2S)-3-cyclohexyl-2-[(2R)-oxolan-2-ylformamido]-N-...)
Affinity DataKi:  582nMAssay Description:The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2007
Entry Details Article
PubMed
TargetCathepsin K(Human)
Gnf

LigandPNGBDBM19707((2S)-3-cyclohexyl-2-[(2R)-oxolan-2-ylformamido]-N-...)
Affinity DataKi:  4.61E+3nMAssay Description:The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2007
Entry Details Article
PubMed