BDBM19710 (3S)-oxolan-3-yl N-[(1S)-2-cyclohexyl-1-{[(2S)-1-{[4-(trifluoromethoxy)phenyl]amino}propan-2-yl]carbamoyl}ethyl]carbamate::arylaminoethyl amide deriv. 24

SMILES C[C@@H](CNc1ccc(OC(F)(F)F)cc1)NC(=O)[C@H](CC1CCCCC1)NC(=O)O[C@H]1CCOC1

InChI Key InChIKey=ZWWCAZDZUZLYET-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 19710   

TargetCathepsin S(Human)
Gnf

LigandPNGBDBM19710((3S)-oxolan-3-yl N-[(1S)-2-cyclohexyl-1-{[(2S)-1-{...)
Affinity DataKi:  49nM ΔG°:  -10.4kcal/molepH: 5.5 T: 2°CAssay Description:The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2007
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Gnf

LigandPNGBDBM19710((3S)-oxolan-3-yl N-[(1S)-2-cyclohexyl-1-{[(2S)-1-{...)
Affinity DataKi:  594nMAssay Description:The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2007
Entry Details Article
PubMed
TargetCathepsin K(Human)
Gnf

LigandPNGBDBM19710((3S)-oxolan-3-yl N-[(1S)-2-cyclohexyl-1-{[(2S)-1-{...)
Affinity DataKi: >3.00E+4nMAssay Description:The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2007
Entry Details Article
PubMed