BDBM19724 (2S)-3-cyclohexyl-N-[(2S)-1-(5-fluoro-2,3-dihydro-1H-indol-1-yl)propan-2-yl]-2-(morpholin-4-ylcarbonylamino)propanamide::arylaminoethyl amide deriv. 38

SMILES C[C@@H](CN1CCc2cc(F)ccc12)NC(=O)[C@H](CC1CCCCC1)NC(=O)N1CCOCC1

InChI Key InChIKey=WMOMSFMNBOGEPA-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 19724   

TargetCathepsin S(Human)
Gnf

LigandPNGBDBM19724((2S)-3-cyclohexyl-N-[(2S)-1-(5-fluoro-2,3-dihydro-...)
Affinity DataKi:  87nM ΔG°:  -10.0kcal/molepH: 5.5 T: 2°CAssay Description:The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2007
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Gnf

LigandPNGBDBM19724((2S)-3-cyclohexyl-N-[(2S)-1-(5-fluoro-2,3-dihydro-...)
Affinity DataKi:  512nMAssay Description:The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2007
Entry Details Article
PubMed
TargetCathepsin K(Human)
Gnf

LigandPNGBDBM19724((2S)-3-cyclohexyl-N-[(2S)-1-(5-fluoro-2,3-dihydro-...)
Affinity DataKi:  5.13E+3nMAssay Description:The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2007
Entry Details Article
PubMed