BDBM19761 (2S)-N-[(1R)-2-(benzyloxy)-1-cyanoethyl]-4-methyl-2-{1-[4-(pyridin-4-yl)piperazin-1-yl]acetamido}pentanamide::dipeptidyl nitrile, 16b

SMILES CC(C)C[C@H](NC(=O)CN1CCN(CC1)c1ccncc1)C(=O)N[C@@H](COCc1ccccc1)C#N

InChI Key InChIKey=UZCUBOSCRIAKSH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 19761   

TargetCathepsin K(Human)
Novartis Pharmaceuticals

LigandPNGBDBM19761((2S)-N-[(1R)-2-(benzyloxy)-1-cyanoethyl]-4-methyl-...)
Affinity DataIC50: 9nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Novartis Pharmaceuticals

LigandPNGBDBM19761((2S)-N-[(1R)-2-(benzyloxy)-1-cyanoethyl]-4-methyl-...)
Affinity DataIC50: 330nMpH: 5.5 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetCathepsin S(Human)
Novartis Pharmaceuticals

LigandPNGBDBM19761((2S)-N-[(1R)-2-(benzyloxy)-1-cyanoethyl]-4-methyl-...)
Affinity DataIC50: 180nMAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed