BDBM197677 US9216981, 5::US9550781, 1

SMILES CCCS(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F

InChI Key InChIKey=ZCFRMOFRDWXLRB-UHFFFAOYSA-N

Data  5 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 197677   

TargetSerine/threonine-protein kinase B-raf(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM197677(US9216981, 5 | US9550781, 1)
Affinity DataIC50: 9nMAssay Description:Inhibition of B-Raf V600E mutant (unknown origin) assessed as MEK1 phosphorylation using MEK1-Avitag as substrate after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2017
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM197677(US9216981, 5 | US9550781, 1)
Affinity DataIC50: 12nMAssay Description:Inhibition of wild type B-Raf (unknown origin) assessed as MEK1 phosphorylation using MEK1-Avitag as substrate after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2017
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM197677(US9216981, 5 | US9550781, 1)
Affinity DataIC50: 23nMpH: 7.2 T: 2°CAssay Description:To check the B-Raf kinase inhibitory activity of the compounds of the present invention, the following experiments were conducted.(1) Serial Signalin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2016
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM197677(US9216981, 5 | US9550781, 1)
Affinity DataIC50: 24nMAssay Description:Inhibition of B-Raf V600E mutant in human A375 cells assessed as ERK phosphorylation preincubated for 1 hr by Western blot methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2017
Entry Details Article
PubMed
TargetNuclear receptor coactivator 2 [740-753]()
Centaurus Biopharma

US Patent
LigandPNGBDBM197677(US9216981, 5 | US9550781, 1)
Affinity DataIC50: 100nMAssay Description:In vitro B-RAF Kinase Assay. To determine iIn vitro activities of recombinant B-RAF enzyme, a Homogeneous Time-Resolved Fluorescence (HTRF) assay was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2018
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM197677(US9216981, 5 | US9550781, 1)
Affinity DataEC50:  310nMT: 2°CAssay Description:To check the B-Raf cell activity inhibitory capability of the compounds of the present invention, the following experiments were conducted in A375P c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2016
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM197677(US9216981, 5 | US9550781, 1)
Affinity DataEC50:  936nMAssay Description:Inhibition of wild type B-Raf in human MIAPaCa2 cells assessed as reduction in ERK phosphorylation preincubated for 1 hr by Western blot methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2017
Entry Details Article
PubMed